Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy
The improvement in spatial learning in late life following early adulthood chronic sleep disruption in PS19 mice would seem disentangled from an effect on tauopathy or neurodegeneration, but whether the behavioral consequence is related to the observed changes in hippocampal microglial density remains to be mechanistically linked.