Author

Richard L. Gieseck

2 papers indexed here

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Open access Oct 2026

TCF21 loss identifies a conserved inflammation-associated fibroblast state across Crohn’s disease and ulcerative colitis

Background and Aims Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are associated with stromal remodeling; however, the fibroblast states that contribute to chronic inflammation remain incompletely defined. We aimed to identify conserved pathogenic fibroblast programs acr...

Mor Hindi Malowany, Noah Franklin, Matthew V. Russo et al. · bioRxiv · 0 citations

Open access Aug 2026

Combined type 2 cytokine blockade enhances PD-1-mediated antitumor immunity.

Immune checkpoint inhibitors improve outcomes for many patients with cancer, but resistance remains a major clinical challenge. Type 2 cytokines, including IL-4, IL-13, and thymic stromal lymphopoietin (TSLP), have been implicated in suppressing anti-tumor immunity. Here, we investigated whether combined blockade of IL...

T. Fabre, Eleanore Hendrickson, K. McGourty et al. · Cell Reports · 0 citations