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Author

R. Harris

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Open access Sep 2026

A Trisomy 21 Model Atlas reveals conserved dosage effects and context-specific transcriptional responses across mouse and human models of Down syndrome

Trisomy 21, the genetic basis of Down syndrome, causes widespread transcriptional dysregulation with tissue-specific phenotypic consequences, but how this propagates across tissues, developmental stages, and model systems remains incompletely understood. We present the initial release of the Trisomy 21 Model Atlas, com...

K. Rossmassler, Ariel E. Timkovich, Brian F. Niemeyer et al. · 0 citations
Open access Aug 2026

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing

This study provides a high-resolution transcriptional atlas of canine hematopoiesis and highlights conserved regulatory programs between dogs and humans, offering a reference for future studies of hematologic disease and cross-species comparisons.

Dylan T. Ammons, Christopher Contursi, McKenzie Olsen et al. · 2 citations

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