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Author

R. Hartkoorn

2 papers indexed here

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Open access Sep 2026

Siderophore-Enabled Delivery of Carbapenem and Metallo-β-Lactamase Inhibitor: A Promising Strategy against Multidrug-Resistant Pseudomonas aeruginosa

Carbapenem-resistant Pseudomonas aeruginosa (CRPA), a World Health Organization high-priority pathogen, represents a major clinical threat due to limited treatment options. Its intrinsic resistance is driven in part by extremely low outer-membrane permeability, which restricts antibiotic uptake, while the increasing...

Shahriar Safari, Ravil Petrov, Y. Ustimenko et al. · 0 citations
Open access Sep 2026

Inhibition of type II NADH dehydrogenase in Mycobacterium tuberculosis reveals collateral vulnerability in the electron transport chain

ABSTRACT To sustain the anti-tuberculosis drug development pipeline, novel antibiotics must be developed both as standalone agents and as components of future combination regimens. To this end, tricyclic-spirolactams (TriSLa)-based inhibitors of mycobacterial type II NADH dehydrogenase (Ndh-2) represent a promising nov...

Vien Q. T. Ho, Vincent Fontaine, Ernesto Anoz-Carbonell et al. · 0 citations

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