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Review Open access Sep 2026

552. Can locus coeruleus structural and functional changes serve as a biomarker for Alzheimer's disease: a systematic review and meta-analysis

Con convergent evidence supports LC vulnerability in AD, including LC-related pathological burden and degeneration with accompanying noradrenergic alterations, and the need for standardized LC acquisition/segmentation and larger, longitudinal cohorts to establish robust diagnostic and prognostic utility.

Y. Zhou, M. Ali, R. Hou · 0 citations

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