Author

R. J. Hulswit

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Open access Aug 2026

Spike and host glycan determinants of HKU1 airway tropism

It is shown that spikes from both serotypes of HKU1 preferentially bind 9-O-acetylated α2,8-linked disialosides, and molecular dynamics simulations indicated that membrane-embedded GT3, but not GD3, presents its glycan chain in a geometry compatible with S1A-mediated engagement.

Robert Creutznacher, Louisa Elizabeth Wallace, Oliver J. Debski-Antoniak et al. · bioRxiv · 0 citations