Open access
Jul 2026
Combinatorial MAPK states drive opposing gene programmes: a reanalysis of MAP3K-driven transcriptional responses in MCF10A cells
It is demonstrated that MAP3Ks co-activating ERK and JNK drive approximately tenfold more cell cycle entry than MAP3Ks activating ERK alone, and that both kinase activities are independently required for this proliferative response.
M. Solé, Beatriz Candás-Estébanez, R. K. da Palma et al.
· bioRxiv · 0 citations