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Oct 2026

Integrative Evolutionary and Structural Analysis of GBA1 Provides Insights Into Mutation-Specific Effects Associated With Parkinson's Disease.

GBA1 encodes lysosomal acid β-glucosidase (glucocerebrosidase [GCase]), a key lysosomal enzyme and one of the most important genetic factors in Parkinson's disease (PD). Yet how different GBA1 variants influence PD-related molecular pathology remains incompletely understood. Here, we integrated phylogenetic, comparativ...

Sania Mustafa, A. Abbasi, Kashifa Akhtar Mughal et al. · 0 citations
Oct 2026

Integrating deep learning model for precision design of MERS antibodies with augmented affinity against SARS-CoV-2.

The rapid emergence of SARS-CoV-2 has renewed interest in cross-reactive antibody therapeutics targeting conserved epitopes across divergent coronaviruses. Building on our deep-learning driven protein engineering pipeline, we sought to redirect experimentally validated MERS-CoV antibodies toward the SARS-CoV-2 receptor...

Areesha Irshad, Atta Ur-Rehman, Taskeen Koser et al. · 0 citations

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