Author

R. Knight

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Open access Nov 2026

Industrialization drives convergent microbiome and host physiological shifts in the human metaorganism.

Understanding how industrialization reshapes the human metaorganism requires integrating microbiome ecology with host physiology across globally diverse populations. Here, we generate multivariate data from the Global Microbiome Conservancy cohort, including gut microbiome, immunoglobulin A (IgA) sequencing, host genot...

M. Poyet, M. Rühlemann, A. Schaan et al. · Cell · 1 citation

Open access Sep 2026

Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics

Standard metagenomics resolves microbial communities only in relative terms and at coarse taxonomic resolution, obscuring how individual strains change in absolute abundance and evolve within a host1–6. We present long-read quantiomics (LRQ), a quantitative metagenomics platform coupling long-read sequencing with plasm...

M. O. Din, C. Brennan, Jian-Shu Zhao et al. · bioRxiv · 0 citations

Open access Aug 2026

Joint-RPCA: domain-aware multi-omics integration for systems microbiology.

Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.

Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al. · Molecular Systems Biology · 1 citation