Author

R. Koche

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Open access Sep 2026

Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints

Sensitive detection of minimal residual disease (MRD) remains a major unmet need in high-risk neuroblastoma. MYCN amplification, a hallmark of high-risk disease, typically occurs on extrachromosomal DNA (ecDNA), but the potential of ecDNA-associated genomic rearrangements for individualized MRD monitoring has not been...

A. Szymansky, F. Hertwig, A. Winkler et al. · bioRxiv · 0 citations

Open access Aug 2026

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.

Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al. · Nature · 0 citations