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Exposure to air pollution may be associated with greater risk of PD, and SES may play a role in the degree of air pollution exposure.
This review critically examines the molecular and clinical spectrum of GBA1 -associated PD, highlighting the relationship between variant severity, lysosomal dysfunction, and disease progression, and summarizes emerging disease-modifying therapeutic strategies, including small-molecule GCase activators, pharmacological...
Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.
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