R. L. Roberts

In vivo screen for osteoclast derived osteogenic factors using non-resorptive osteoclasts in zebrafish bone.

Bone homeostasis requires the balanced action of bone forming osteoblasts and bone resorbing osteoclasts. This balance is maintained through local as well as systemic factors. Loss of osteoclast resorptive activity leads to development of osteopetrosis with increased bone volume but reduced skeletal integrity. Identifi...