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Author

R. L. T. de Morais

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Review Open access Oct 2026

The Pesticide Pyrethroid Metabolite 3-Phenoxybenzoic Acid (3-PBA) Impairs Human Cardiac Nav1.5 and Action Potential Depolarization

This study demonstrates that 3-PBA interacts with human cardiac Nav1.5 expressed in Human Embryonic Kidney (HEK293) cells, and significantly increases INa-L in a concentration-dependent manner with an EC50 of 51.3 ± 5.1 µM, and suggests that its cardiotoxic potential may become clinically relevant under conditions of h...

Michael Ramon de Lima Conceição, L. Marques, Fabiana da Silva Alcântara et al. · 0 citations

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