Abstract A048: TGFBR2 dysfunction rewires cell cycle, MAPK signaling, and migration in pancreatic cancer
The results suggest that PKT tumor aggressiveness may be attributed to preferential activation of cell cycle-associated programs over EMT-associated migration programs, and support G1/S cell cycle regulation as a potential vulnerability for combination therapy with KRASG12D inhibition or chemotherapy in TGFBR2-mutant o...