Genetic Correlates of Malignant Behavior in Aggressive Pituitary Tumors.
OBJECTIVE Aggressive pituitary neuroendocrine tumors (PitNETs) that progress despite surgery, radiotherapy (RT), and medical therapy are heterogenous; only a subset exhibits overtly malignant behavior. We examined genetic determinants of metastatic behavior and poor prognosis. DESIGN Retrospective genomic cohort stud...