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Open access Sep 2026

Gene-family-dependent thermodynamic effects of oncogenic mutations on nucleosome-DNA binding stability: a comparative molecular dynamics study across 22 cancer hotspots

Oncogenic mutations are known to occur at non-random rates and specific hotspots, yet the structural and thermodynamic factors underlying these hotspots remain poorly understood. This study presents molecular dynamics simulations of 22 cancer hotspots across 10 oncogene families, simulated as histone-DNA complexes. Acr...

Shlomo Freudenberger, Evan Boczko, S. Goel et al. · 0 citations
Review Oct 2026

Participation of Patients With Gynecologic Cancer in Phase I Clinical Trials: Experience From Two National Cancer Institute-Designated Comprehensive Cancer Centers.

PURPOSE Phase I trials are intended to define the safety of novel therapeutics, yet they offer alternative options long before they are approved. Limited data exist regarding access to and participation in phase I trials among gynecologic oncology patients. The purpose of this study is to assess the efficacy, toxicitie...

Anusha Adkoli, Charlotte Hadjadj, Krystle Vera et al. · 0 citations

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