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Rond Malhas

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Open access Oct 2026

Locus coeruleus intensity as a marker of early-stage Alzheimers disease: associations with plasma pTau217 and memory

INTRODUCTION: The locus coeruleus (LC) is one of the earliest sites of Alzheimers disease (AD) pathophysiological changes. LC magnetic resonance imaging (MRI) intensity may reflect effects of AD pathophysiology on the LC, providing a biomarker of early-stage AD. This study examined relationships among MRI-derived LC in...

M. Quiring, Y. Shuai, W. Zhao et al. · 0 citations
Open access Jul 2026

Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease

Higher plasma YKL‐40 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F‐florbetapir (FBP) standardized uptake value ratio (SUVR) and higher plasma p‐tau217 was associated with reduced MTL cortical thickness and hippocampal volume.

Batool Rizvi, Jenna N. Adams, Alison R. Bamford et al. · 1 citation

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