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Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder
The integration analysis showed that genetic variants and DNA methylation at sites annotated to the FADS gene cluster were linked with lipid species that were also associated with lifetime MDD status, while introducing DNA methylation as an additional molecular layer supporting this link.
Blood DNA Methylation Predicts Long-Term Risk of Dementia in Prospective Cohorts
Findings support cg05917797 as a reproducible blood-based epigenetic marker of long-term dementia risk and higher methylation at cg05917797 was associated with lower Braak stage in temporal gyrus and cerebellum.