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Author

R. Mariuzza

2 papers indexed here

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Open access Aug 2026

Structural basis for T-cell receptor recognition of p53Y220D, a human cancer neoantigen.

Adoptive cell therapy (ACT) with tumor-specific T cells can mediate durable cancer regression. The main target of tumor-specific T cells are neoantigens resulting from mutations in self-antigens over the course of malignant transformation. To understand T-cell recognition of cancer neoantigens at the atomic level, we s...

Zhihui Duan, Jian-Feng Zhao, Junping Wu et al. · 0 citations
Open access Jul 2026

Structural basis for oligoclonal T cell recognition of a shared NRAS cancer neoantigen.

The structures explain how the NRASQ61K mutation rendered a self-antigen visible to T cells and provide stringent tests for computational modeling of TCR-peptide-MHC interactions relevant to cancer immunotherapy.

V. Sharma, D. T. Gallagher, S. Saravanakumar et al. · 0 citations

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