BACKGROUND
Ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC) encode the value of stimulus and outcome phases in a context-dependent manner to support motivated behaviour. In psychosis, disrupted motivational coding has been hypothesised to contribute to negative symptoms via reduced sensitivity to goal-r...
C. Zauchenberger, L. Vano, M. Veronese et al.· Biological Psychiatry· 0 citations
RATIONALE
Tardive dyskinesia (TD) is a neurological syndrome of involuntary repetitive movements which results from treatment with antipsychotic medication. The pathoetiology of TD is not well understood but a possible mechanism involves dopaminergic overactivity in the nigrostriatal pathway. If this theory is correct,...
B. Bukala, L. Vano, Richard Carr et al.· Psychopharmacology· 0 citations
It is found that rapid relapse was not over-represented among those who discontinued treatment, which is not the pattern expected if rapid relapse following paliperidone discontinuation were commonly a pharmacological discontinuation effect.
Krisya Louie, S. Jauhar, J. Rubio et al.· Lancet psychiatry· 1 citation
It is suggested that effective treatment weakens maladaptive symptom coupling, offering new insights into the mechanisms of clinical improvement and potential targets for intervention.
Elizabeth A. Kenny, B. Brand, O. Ebrahimi et al.· The British journal of psych...· 0 citations
These findings bridge genetic risk at the 22q11.2 locus with dopamine dysfunction and large-scale networks, offering novel insights into the neurobiology of 22q11DS and related neuropsychiatric risk.
V. Mancini, M. Rogdaki, S. Jauhar et al.· Molecular Psychiatry· 0 citations
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