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Open access Sep 2026

Surgical outcomes after robot-assisted versus laparoscopic pancreatoduodenectomy: multicentre propensity-matched comparison from the Italian Group of Minimally Invasive Pancreatic Surgery

Abstract Background Minimally invasive approaches to pancreatoduodenectomy (PD) are increasingly being adopted worldwide. However, direct comparisons between laparoscopic PD (LPD) and robot-assisted PD (RPD) remain limited and inconclusive. This study aimed to compare perioperative outcomes between LPD and RPD within a...

G. Quero, R. Menghi, N. Napoli et al. · 0 citations
Review Open access Jul 2026

Patient-derived organoids in functional precision oncology: from experimental models to clinical decision-making

Despite major advances in high-throughput genomics, proteomics, and multimodal imaging, a substantial gap persists between molecular tumor characterization and clinically actionable therapeutic decision-making, partly due to the limitations of conventional preclinical models in capturing tumor heterogeneity and predict...

Amanda Caruso, A. Delvecchio, R. Memeo et al. · 1 citation
Review Open access Aug 2026

Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives

The development of patient-derived organoids (PDOs) has substantially advanced the study of gastrointestinal diseases by providing three-dimensional human models that faithfully recapitulate the structural, molecular, and functional characteristics of native tissues. Unlike conventional two-dimensional cultures and ani...

Amanda Caruso, Yasmine Hamrouni, A. Delvecchio et al. · 0 citations

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