R. Mirmira

A Novel PD-L1 Splice Isoform Modulates β Cell Communication in Response to Interferon Signaling

β cell expression of the immune checkpoint ligand PD-L1 (encoded by CD274) limits autoimmune β cell destruction in type 1 diabetes (T1D). β cell display PD-L1 not only at the cell surface but also secreted on extracellular vesicles (EVs), which bind PD-1 and restrain CD8+ T cell activation. β cell IFN signaling is an e...