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R. Puliga

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Open access Sep 2026

Mesocortical dopamine hypofunction and prefrontal plasticity deficits in the cuprizone model.

It is suggested that cuprizone-induced intoxication disrupts VTA-mPFC circuitry, leading to mesocortical dopamine hypofunction, altered cortical plasticity, and executive dysfunction, and support targeting mesocortical dopamine transmission as a potential strategy for MS-related cognitive symptoms.

Laura Dazzi, G. Talani, F. Biggio et al. · 0 citations

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