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Sep 2026

Serum Metabolomic Profiles Unveil Biomarkers and Core Metabolic Pathways in Multiple System Atrophy Patients.

BACKGROUND Multiple system atrophy (MSA) is an adult-onset, fatal, neurodegenerative disease lacking mechanistic understanding, early diagnosis, and specific treatments. Metabolomics has been widely used in neurodegenerative diseases for biomarker identification and pathophysiology exploration; however its application...

Lin-Lin Wan, Zhao Chen, Na Wan et al. · 0 citations
Review Sep 2026

An Atlas of Modifiers of Age at Onset in Huntington's Disease.

BACKGROUND Huntington's disease (HD) is a fatal neurodegenerative disorder lacking effective treatment. The relationship between modifiable factors and age at onset (AAO) in HD remains controversial and causally unconfirmed. Identifying causal modifiers of AAO is crucial for delaying onset and disease prevention. MET...

Lin-Liu Peng, Zhao Chen, Lin-Lin Wan et al. · 0 citations

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