Open access
Sep 2026
DPYD c.85T>C, DPYD c.496A>G, and DPYD c.2194G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.
Current DPYD genotyping panels used to prevent fluoropyrimidine (FL)-related toxicity explain only a limited proportion of severe adverse events. The clinical relevance, beyond current testing, of additional DPYD variants, including DPYD⁎6 (c.2194G>A, rs1801160), DPYD c.496A>G (rs2297595), and DPYD⁎9A (c.85T>C, rs18012...
E. De Mattia, J. Polesel, M. van der Lee et al.
· Pharmacological Research · 0 citations