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Open access Sep 2026

Ethambutol Population Pharmacokinetics and Pharmacodynamics from a Phase 3 Confirmatory Trial for the Treatment of Tuberculosis

Background: Ethambutol, a longstanding treatment for tuberculosis, lacks comprehensive pharmacokinetic data, particularly regarding covariates affecting exposure and their link to treatment outcomes. Using the largest data to date from Study 31/AIDS Clinical Trials Group A5349, we aimed to characterize ethambutol pharm...

S. Alkhafaji, E. Yang, Kaylee Lee et al. · 0 citations
Open access Sep 2026

Connecting the Dots Between Pharmacokinetics, Inflammatory Biomarkers, and Mucosal Healing in Patients on Infliximab with Inflammatory Bowel Disease

Background/Objectives: Mucosal healing (MH) is a key therapeutic target in inflammatory bowel disease (IBD) associated with sustained remission, reduced hospitalisation, and improved outcomes. Its assessment relies on endoscopic evaluation, which is invasive, costly, and not always feasible. Therapeutic drug monitoring...

Ana Homšek Ilić, M. Jovanović, S. Marković et al. · 0 citations

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