Author

R. Scharfmann

3 papers indexed here

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Sep 2026

Parallel regulation of tissue morphogenesis and cell fate specification by RAR:RXR signalling during pancreas formation.

During embryogenesis, morphologically diverse epithelial organs bud from different regions of the embryonic gut. The unique features of each nascent organ result from distinct cell fate specification and morphogenetic events elicited by organ-inducing cues. Retinoic acid is a powerful inducer of the pancreas, yet, how...

Ivan Kulik, Cheng-Lei Tian, Sabina Chubanava et al. · Development · 0 citations

Open access Sep 2026

Engineering the insulin signal peptide to protect human pancreatic beta cells from autoimmune destruction.

Autoreactive T cells that destroy beta cells in type 1 diabetes are largely targeting insulin signal peptide fragments. HLA knockout beta-cells have been proposed to create hypo-immune cells, but this strategy poses significant tumorigenic risks. Alternatively, we hypothesized that insulin signal peptide modification w...

Farah Kobaisi, Masaya Oshima, Zhi-Cheng Zhou et al. · Cell Reports · 0 citations

Review Open access Aug 2026

Pancreatic islets: new discoveries for innovative treatments of diabetes?

This review has selected recent examples that highlight the progress made in understanding human islets and beta cell biology, and questioned why there is still a gap in knowledge regarding beta cell destruction in type 1 diabetes, despite hundreds of thousands of published studies.

R. Scharfmann, A. Zaldumbide · Diabetologia · 0 citations