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Sep 2026

Targeted Colorectal Cancer Therapy Using Cabozantinib-Loaded PLGA Nanoparticles: Formulation, Cytotoxicity, and Molecular Docking Analysis.

The present study represents improved Cabozantinib delivery via Cabozantinib-loaded poly(lactic-co-glycolic acid) nanoparticles, prepared by solvent evaporation. Nanoparticles had a size of 249.5 ± 12.9 nm, a polydispersity index of 0.18, a zeta potential of +2.61 mV, and an encapsulation efficiency of 19% w/w, reflect...

Aryan Thakkar, Sankha Bhattacharya, R. Shinde · 0 citations
Jul 2026

Formulation and Evaluation of Etoposide-loaded Dextran polymeric nanoparticles fabricated with Hyaluronic acid for the treatment of colorectal cancer using network pharmacology, in-silico, in-vitro, and in-vivo approaches.

Etoposide (ETP), a Biopharmaceutics Classification System class IV drug with poor aqueous solubility, demonstrates limited therapeutic efficacy against colorectal cancer (CRC) because of inferior absorption and off-target effects. To deliver drugs specifically to cancer cells that overexpress CD44, this study developed...

Hrushikesh Wagh, Sankha Bhattacharya, P. Sangave et al. · 0 citations

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