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Author

R. Singh

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Review Open access Sep 2026

The P2X7R-NLRP3 inflammasome axis in Alzheimer’s disease and therapeutic potential of synthetic and plant-derived natural compounds: A review

Alzheimer’s disease is a prevalent neurodegenerative disease that is characterized by synaptic dysfunction followed by neuronal loss. The core pathological mechanisms of Alzheimer’s disease include the extracellular deposition of amyloid beta (Αβ) plaques and intracellular neurofibrillary tangle deposits inside the b...

Rishabh Goswami, Nidhi Sharma, V. Jhawat et al. · 0 citations
Review Open access Sep 2026

Herbal nanoparticles in the treatment of neurodegeneration: from molecular mechanisms to therapeutic translation

This review critically summarizes recent advances in herbal nanoformulations, emphasizing disease-specific molecular targets, BBB-targeting strategies, comparative nanocarrier systems, pharmacokinetic optimization, intracellular trafficking, and translational challenges.

D. Mittal, Pavitra Solanki, G. K. Jain et al. · 1 citation
Review Jul 2026

TARGETING ALZHEIMER’S DISEASE WITH CARNOSIC ACID: THERAPEUTIC MODULATION OF THE P2X7 RECEPTOR–NLRP3 INFLAMMASOME PATHWAY IN RAT MODELS

What is known today as to the role of P2X7 receptor and NLRP3 inflammasome in the pathogenesis of Alzheimer disease is summarized and whether carnosic acid can act as neuroprotective in preclinical rat models is critically assessed.

Sonia Sonia, Komal Komal, Abhinash Abhinash et al. · 0 citations
Review Jul 2026

NEUROTHERAPEUTIC POTENTIAL OF CUSCUTA REFLEXA (AMARBAEL): A MULTI-TARGETED HERBAL MODULATOR OF THE P2X7–NLRP3 INFLAMMASOME AXIS IN ALZHEIMER’S DISEASE

This review critically examines the neurotherapeutic potential of Cuscuta reflexa as a multi-target modulator of the P2X7–NLRP3 inflammasome axis in Alzheimer’s disease and proposes a mechanistic framework through which Cuscuta reflexa may attenuate chronic neuroinflammation, preserve synaptic integrity, and support ne...

Komal Bhiduri, Abhinash Saini, D. Dhull et al. · 0 citations

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