Author

R. Stauber

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Open access Sep 2026

mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation

The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that altered hepatic mTORC1–TFEB/TFE3 signaling is associated with coordinated rem...

A. Zaufel, Wenfei Sun, N. Pastore et al. · Science Advances · 0 citations

Open access Aug 2026

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

ABSTRACT Classical histology remains the gold standard for liver fibrosis assessment but is limited by destructive sectioning, 2D information, and sampling bias. Micro‐CT offers non‐destructive 3D imaging, yet conventional contrast agents can compromise tissue integrity and downstream analyses. This study establishes a...

Kristijan Skok, Laura Činč Ćurić, Jernej Vajda et al. · Advancement of science · 0 citations