Author

R. Sudharshan

h-index 1 View on Semantic Scholar

We have 2 of 6 papers

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Sep 2026

Abstract B076: Tumor cell-intrinsic KMT2D loss regulates T cell function through FN1 signaling in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies and is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that limits the efficacy of current therapies. KMT2D (Mll4 in mice) is a histone H3K4 methyltransferase and critical epigenetic regulator that is altere...

Heizel Acosta, R. Sudharshan, Hongsun C. Kim et al. · Cancer Research · 0 citations

Open access Jul 2026

Epigenetic Tumor Suppressor KMT2D Shapes the Immune Landscape in Pancreatic Cancer 2335260

KMT2D plays a pivotal role in orchestrating both tumor-intrinsic and microenvironmental processes that drive pancreatic cancer progression, and understanding how KMT2D loss reprograms the immune landscape may uncover novel immunomodulatory therapeutic targets for pancreatic cancer.

H. Acosta-Vilanova, H. Kim, Shungang Zhang et al. · Journal of Immunology · 0 citations