Open access
Sep 2026
In Vitro Responsiveness of 417 CFTR Variants to Vanzacaftor/Tezacaftor/Ivacaftor.
BACKGROUND This study sought to identify additional rare CFTR variants that show improved chloride (Cl⁻) transport in response to the modulator combination vanzacaftor/tezacaftor/ivacaftor (VNZ/TEZ/IVA; VTI). It builds on prior work evaluating 655 variants treated with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA; ETI...
H. Bihler, Andrey Sivachenko, Priyanka Bhatt et al.
· Journal of Cystic Fibrosis · 0 citations