Biological mechanisms underlying the cardiovascular effects of branched-chain amino acids: A proteome-wide Mendelian Randomization Study.
BACKGROUND Ischemic heart disease (IHD) is the leading cause of morbidity and mortality. Branched-chain amino acids (BCAAs) are associated with higher IHD risk, but the underlying biological pathways remain unclear. OBJECTIVE This study aims to explore these pathways using two-step proteome-wide Mendelian randomizati...