Bacteria employ molecular mimicry to hijack host cellular functions for their own benefit. Despite the wealth of data mapping human-bacteria interactions, a comprehensive view of how these networks are fine-tuned remains elusive. In particular, there have been no large-scale screenings measuring human-bacterial protein...
Jaime Fernandez-Macgregor, L. Ilari, Fabien Durbesson et al.· bioRxiv· 0 citations
There is a growing interest in methods that illuminate the contributions of individual positions to a protein’s function by site-saturating mutagenesis. However, a commonly used approach for assessing variant libraries with deep mutational scanning relies on readouts of biological fitness, which is influenced by many p...
Pierce T. O'Neil, Tonya N. Zeczycki, Kyung-Tae Park et al.· Biophysica· 0 citations
It is demonstrated that Adh2 suppresses Agr signaling and virulence gene expression while promoting a persistent phenotype, and emerges as a promising candidate for therapeutic modulation of bacterial behavior, particularly in the context of chronic wound infections.
Riham Daher, P. François, R. Vincentelli et al.· Virulence· 0 citations
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