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R. Vincentelli

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Open access Oct 2026

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

Bacteria employ molecular mimicry to hijack host cellular functions for their own benefit. Despite the wealth of data mapping human-bacteria interactions, a comprehensive view of how these networks are fine-tuned remains elusive. In particular, there have been no large-scale screenings measuring human-bacterial protein...

Jaime Fernandez-Macgregor, L. Ilari, Fabien Durbesson et al. · 0 citations
Open access Aug 2026

Amber Suppressor tRNA-Based Mutagenesis for Positional Semi-Saturated Mutagenesis with Natural Amino Acid Substitutions: An Approach for Mapping Positional Contributions to Protein Function

There is a growing interest in methods that illuminate the contributions of individual positions to a protein’s function by site-saturating mutagenesis. However, a commonly used approach for assessing variant libraries with deep mutational scanning relies on readouts of biological fitness, which is influenced by many p...

Pierce T. O'Neil, Tonya N. Zeczycki, Kyung-Tae Park et al. · 0 citations
Open access Jul 2026

A secreted AIP-Like peptide from Helcococcus kunzii inhibits the Agr quorum sensing system of Staphylococcus aureus

It is demonstrated that Adh2 suppresses Agr signaling and virulence gene expression while promoting a persistent phenotype, and emerges as a promising candidate for therapeutic modulation of bacterial behavior, particularly in the context of chronic wound infections.

Riham Daher, P. François, R. Vincentelli et al. · 0 citations

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