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Open access Aug 2026

Protein language models and the long tail of functional diversity

It is found that many GigaRef singletons belong to a cluster under alternative parameter settings, suggesting that genomic and metagenomic datasets may require dataset-specific clustering configurations, and it is shown that singletons share mutual information with clustered sequences, making them learnable by PLMs and useful for training.

R. Vinod, Samir Char, Ava A. Amini et al. · 0 citations