Multiscale Brownian dynamics simulations reveal effects of macromolecular crowding on protein-ligand association.
Macromolecular crowding is known to influence the diffusive, binding, kinetic, and equilibrium properties of proteins in a range of environments such as occur inside biological cells or in highly concentrated solutions of protein therapeutics. However a quantitative understanding of the effects of macromolecular crowdi...
Riccardo Beccaria, Abraham Muñiz-Chicharro, R. Wade
· Proceedings of the National... · 0 citations