Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4+ TH17 Cells
The differentiation of naïve CD4+ T cells into effector T cell subsets such as TH1, TH2, TH17 and TREG cells is governed by tightly coordinated activation programmes dependent on T cell receptor (TCR) engagement, co-stimulation, and cytokine signalling. This differentiation process involves regulation of stress-respons...