Rabab Jameel Hashim

1,3,4-Oxadiazole derivatives as potential anti-glioma agents: synthesis, characterization, in vitro cytotoxic activity against HS683 cells, and molecular docking

The 1,3,4-oxadiazoles were synthesized by acid-catalyzed condensation of the hydrazides with aromatic aldehydes to give the hydrazones, which were then oxidized to the corresponding 1,3,4-oxadiazoles using I 2 /K 2 CO 3 in DMSO. Characterization was carried out by FT-IR, 1 H NMR, 13 C NMR, and EI mass spect...