Author

Rabi Murad

2 papers indexed here

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Sep 2026

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.

Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini et al. · bioRxiv · 0 citations

Open access Jul 2026

Mitochondrial metabolism and epigenetic crosstalk drive SASP

Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP)1. Cytosolic mitochondrial nucleic acids activate innate immune signalling to initiate this inflammatory programme2,3. Here we show that mitochondrial metabolism provides a second layer of control that enables...

Hélène Martini, Jodie Birch, Francisco D M Marques et al. · Nature · 3 citations