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Rachana Menon

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Open access 2026

Hyperglycemia-Induced Oxidative Stress and Inflammatory Signaling in the Pathogenesis of Type 2 Diabetes Mellitus

Insulin resistance arises from serine phosphorylation of insulin receptor substrate (IRS) proteins mediated by stress kinases such as c-Jun N-terminal kinase (JNK) and IκB kinase-β (IKKβ), compounded by lipotoxic and cytokine-driven signaling defects. Sustained hyperglycemia diverts glucose flux into four classical pat...

Rachana Menon, Deepak N. Parchwani, Mehul Kaliya et al. · 0 citations

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