Open access
Aug 2026
Reprogramming Cas9 PAM Recognition for Allele-Specific Editing
A yeast selection platform is developed to engineer Cas9 with re-specified activity across multiple additional non-canonical PAMs in yeast, further demonstrating its utility as a general and programmable framework for expanding the therapeutic reach of precision genome editing.
Julia Tartaglia, Vivian Nguyen, John James Desmarais et al.
· bioRxiv · 0 citations