The levonorgestrel-releasing intrauterine system (LNG-IUS) acts predominantly at the endometrial level without consistently suppressing the hypothalamic–pituitary–gonadal axis. Residual ovarian activity may persist, occasionally resulting in functional follicular cysts capable of producing estradiol. Serum estrad...
Marina P. Bezerra de Menezes, Rachel Petrola, Milena G. Teles et al.· Clinical Chemistry· 0 citations
Low-density lipoprotein cholesterol (LDL-C) remains the primary target for cardiovascular risk reduction; however, it reflects cholesterol content rather than the total number of circulating atherogenic particles. Apolipoprotein B (ApoB), present in one copy per atherogenic lipoprotein particle, more directly rep...
M. Bezerra, Alice Petrola Bezerra Sayao, Rachel Petrola et al.· Clinical Chemistry· 0 citations
Indirect immunofluorescence (IIF) on HEp-2 cells remains the reference standard for ANA screening, providing semi-quantitative titers and clinically relevant fluorescence patterns. Despite its high sensitivity, it lacks specificity, and interpretation is influenced by population characteristics, analytical variab...
Clara Arraes, Rachel Petrola, Lais Masullo· Clinical Chemistry· 0 citations
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