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Author

Rachna Sharma

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Open access Oct 2026

Coupling Luciferase Activation and Bioluminescence Resonance Energy Transfer Enables High-Contrast Red-Window Calcium Imaging.

Genetically encoded bioluminescent calcium indicators enable excitation-free imaging of Ca2+ dynamics with low background and without excitation-associated photobleaching. However, many exhibit lower dynamic ranges than their fluorescent counterparts, motivating the development of new sensor configurations, particularl...

Rachna Sharma, Ying Xiong, Xiao-Qing Tian et al. · 0 citations
Review Open access Jul 2026

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.

H. Ai, Frances H. Arnold, Doug Barrick et al. · 0 citations

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