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Author

Rafael Andrade da Silva

2 papers indexed here

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Open access Aug 2026

The peptide Ac2-26 preserves mitochondrial function and neuronal survival in human retinal cells and organoids under hyperglycemic and inflammatory stress.

Diabetic retinopathy (DR) is a neurodegenerative disease characterized by hyperglycemia-induced inflammation, mitochondrial dysfunction, and progressive neuronal cell death, leading to irreversible vision loss. Retinal ganglion cells (RGCs) are particularly vulnerable to this hostile microenvironment, undergoing apopto...

Rafael Andrade da Silva, Shama Parween, Anna C. Howell et al. · 0 citations
Open access Aug 2026

Annexin A1 as a Key Modulator of Inflammatory, Glial, and Angiogenic Signaling Pathways in Diabetic Retinopathy

Purpose Annexin A1 (AnxA1) regulates inflammation and neovascularization in ocular diseases, influencing growth factor signaling and cytoskeletal dynamics. Accordingly, this study aimed to investigate the role of the AnxA1 protein in diabetic retinopathy (DR) and to understand how its absence affects inflammation and v...

Rafael Andrade da Silva, Luiz Philipe de Souza Ferreira, V. M. de Paiva Roda et al. · 0 citations

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