Author

Rafael Roesler

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Open access Sep 2026

Transcortical Resection of an Insular Low-Grade Glioma Medial to the Porto Alegre Line: Surgical Strategy for Preservation of the Lenticulostriate Arteries. Surgical video.

Introduction: Surgical treatment of dominant insular gliomas requires balancing maximal safe resection with preservation of language and motor function. Tumors extending medial to the Porto Alegre Line (PAL) have close anatomical relationships with the lenticulostriate arteries (LSAs), which represent the principal lim...

G. Isolan, Jurandir Marcondes Ribas-Filho, Rodrigo Ricieri Tonan et al. · BioScience · 0 citations

Open access Sep 2026

PSEN1 Expression Identifies a Developmentally Distinct Favourable‐Prognosis State in SHH α Medulloblastoma

Background Although PSEN1 is best known for its role in Alzheimer’s disease, it also regulates neural development and cerebellar morphogenesis. Medulloblastoma (MB) is the most common malignant pediatric brain tumor and arises from disrupted cerebellar developmental programs. The clinical significance of PSEN1 in MB re...

Julia Vanini, Amanda Thomaz, Marina Müller Lupatini et al. · bioRxiv · 0 citations

Open access Sep 2026

Discovery of a new class based on 6-methoxypyrimidine as efficient low weight reversible inhibitors of SARS-CoV-2 main protease (Mpro) with antiviral activity.

A low molecular weight non-peptide, heterocyclic inhibitor, that inactivates Mpro, an important enzyme for the viral cycle and its inhibition affects replication and infection propagation in SARS-CoV-2.

I. S. Fortes, M. Lopes, T. H. M. Fernandes et al. · Bioorganic chemistry (Print) · 0 citations