Author

Raffaele Piccolo

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Review Open access Oct 2026

Pathway-Guided and Patient-Centered Therapeutic Strategies in Atherosclerotic Cardiovascular Disease.

A novel pathway- and phenotype-based conceptual framework is proposed for individualized ASCVD management and secondary prevention that integrates residual-risk phenotypes with clinical characteristics, comorbidities, vascular territory, and treatment-related considerations to support residual-risk-guided selection of...

M. Canonico, M. Avvedimento, F. Borrelli et al. · European Journal of Preventi... · 0 citations

Open access Oct 2026

Ticagrelor Monotherapy or Aspirin Plus Prasugrel After Percutaneous Coronary Intervention

Background The 2025 American College of Cardiology/American Heart Association guidelines endorse de-escalation to ticagrelor monotherapy after percutaneous coronary intervention (PCI) for acute coronary syndromes (ACSs), whereas the 2023 European Society of Cardiology guidelines recommend 12-month dual antiplatelet the...

Michele Maremmani, Enrico Citerni, O. de Filippo et al. · JACC: Advances · 0 citations

Aug 2026

De-escalation of antiplatelet therapy to evaluate platelet reactivity and clinical outcomes after coronary stenting in patients at high bleeding risk and recent acute coronary syndrome: Rationale and design of the DESC-HBR trial.

DesC-HBR is the first randomized trial directly comparing multiple P2Y12 inhibitor de-escalation strategies in HBR patients post-ACS and will provide information to guide individualized antiplatelet strategies balancing ischemic protection and bleeding mitigation in HBR patients.

Francesco Costa, G. Vizzari, S. Zecchino et al. · Cardiovascular Revasculariza... · 0 citations