Rahila Khuroo

A Transgenic mouse tolerant to syngeneic cancer cells expressing truncated human epidermal growth factor receptor

C57BL/6 mice in which a truncated variant of human EGFR (hEGFRt), lacking the ligand binding domain and cytoplasmic domain, is expressed from the CAG regulatory elements comprised of the CMV enhancer, β-actin promoter, and β-globin poly-adenylation signals are developed.