Open access
Aug 2026
A Simple Method to Distinguish Active and Inactive Aptamers by Analyzing the Ruggedness of the Aptamer Free Energy Landscape
Results indicate that folding landscape organization can be used as a predictor of aptamer activity and establish RCI as a simple, mechanistically interpretable measure for improving candidate prioritization, especially in therapeutic aptamer discovery.
Gopalakrishnan Subramanian, William H. Thiel, Rahul Singh
· bioRxiv · 0 citations