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Rahul Singh

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Open access Aug 2026

A Simple Method to Distinguish Active and Inactive Aptamers by Analyzing the Ruggedness of the Aptamer Free Energy Landscape

Results indicate that folding landscape organization can be used as a predictor of aptamer activity and establish RCI as a simple, mechanistically interpretable measure for improving candidate prioritization, especially in therapeutic aptamer discovery.

Gopalakrishnan Subramanian, William H. Thiel, Rahul Singh · 0 citations

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