Author

Raiees Andrabi

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Open access Jul 2026

Structural characterization of broadly neutralizing and potent V1/V2 apex antibodies elicited in rhesus macaques through immunization 2267435

High-resolution cryo-EM structures of bnAbs isolated over a year after the priming immunization revealed that these antibodies recapitulate the binding modes and structural features observed in human-derived V1/V2 apex bnAbs isolated from chronically infected donors, further supporting the utility of nonhuman primate m...

Ipsita Krishnamurthy, Xuduo Li, R. Andrabi et al. · Journal of Immunology · 0 citations

Open access Aug 2026

Protective pan-betacoronavirus neutralizing antibodies by vaccination

These findings provide proof-of-concept that epitope-focused nanoparticle immunogens can target partially occluded, immunoquiescent bnAb epitopes, laying the groundwork for pan-betacoronavirus vaccines that provide broad protection and strengthen pandemic preparedness.

Panpan Zhou, Ziqi Feng, Wan-ting He et al. · bioRxiv · 0 citations

Open access Aug 2026

Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

The isolation of a human monoclonal antibody from a SARS-CoV-2 convalescent donor that targets the conserved S2 stem helix region is reported, demonstrating the potential of in vitro affinity maturation to expand the neutralization breadth of stem-helix-targeting antibodies across divergent betacoronaviruses.

Panpan Zhou, M. Yuan, Yue-Xiu Zhang et al. · PLoS Pathogens · 0 citations