Sep 2026
Small Molecule Modulation of TERRA RNA Quadruplex Reprograms ALT-Telomere Maintenance.
Telomeric repeat-containing RNA (TERRA) plays a central role in telomere maintenance in telomerase-negative cancers that employ the alternative lengthening of telomeres (ALT) pathway; however, its RNA G-quadruplex (rG4) structures remain underexplored as chemical targets. Here, we report a structure-guided approach to...
Tathagato Bhattacharyya, Sarmistha Pal, Maximillian Braun et al.
· Angewandte Chemie · 0 citations